Antisense oligonucleotides (ASOs) have been an emerging area of drug development that targets the disease source at the RNA level, offering a promising alternative to therapies targeting downstream processes. As some ASO drugs have been approved by the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for clinical applications, more are under evaluation for a wide range of diseases, including COVID-19.
Empowered by leading technology and years of experience in gene therapy development, Creative Biolabs now presents an extensive portfolio of ASO services and products for worldwide clients to help move ASO-related projects faster and more efficiently.
The scientist team offers reliable custom antisense oligonucleotide synthesis in ready-to-use duplex multi-scale quantities, and the ASO produced can be used as structural and mechanistic probes in diverse areas of diagnostic and therapeutic applications.
“We will evaluate the application of ASO and provide a custom project using DNA, 2′-O-Methyl RNA, RNA, or constrained nucleotide bases with phosphorothioate or unmodified internucleotide bonds. The services are supported by our in-house bioanalytical laboratory with a full spectrum of analytical tools capable of producing technically challenging yet safe and efficacious drug candidates,” introduced by a senior scientist in ASO team at Creative Biolabs.
In addition to the custom ASO synthesis service, Creative Biolabs also offer a series of ready-to-use ASO products for various disease research, covering cancer, cytomegalovirus retinitis, familial hypercholesterolemia, viral hemorrhagic fever, HIV/AIDS, spinal muscular atrophy, Duchenne muscular, hypertriglyceridemia and other human diseases.
- BCR-ABL (BCR-exon 1/ABL-exon 2) Antisense Oligonucleotide, aBCR-ABL.Oligo1
- IL-15 (IL-15) Antisense Oligonucleotide, aIL-15.Oligo12
- Arenavirus (Arenavirus) Antisense Oligonucleotide, aArenavirus.Oligo3
- IDUA (IDUA) Antisense Oligonucleotide, aIDUA.Oligo1
All the ASO products are of comprehensive backbones and modifications, and flexible synthesis scales and bulk orders are available upon request.
Creative Biolabs is dedicated to exploiting the full potential of ASOs as novel therapeutic interventions, and supporting related research through the team’s deep understanding of new and emerging disease targets across therapy areas. Find more information on the official website https://www.creative-biolabs.com/gene-therapy/.
About Creative Biolabs
With years of experience in providing one-stop preclinical development services, Creative Biolabs has built a team of experts with solid knowledge of gene therapy, and is fully competent in providing services for worldwide clients. The services include but are not limited to delivery vehicle development, gene editing, RNAi therapy development, safety and toxicology analysis, potency tests, and solutions of specific gene therapy development for diseases.